The primary periodic paralyses: diagnosis, pathogenesis and treatment
نویسندگان
چکیده
منابع مشابه
The primary periodic paralyses: diagnosis, pathogenesis and treatment.
Periodic paralyses (PPs) are rare inherited channelopathies that manifest as abnormal, often potassium (K)-sensitive, muscle membrane excitability leading to episodic flaccid paralysis. Hypokalaemic (HypoPP) and hyperkalaemic PP and Andersen-Tawil syndrome are genetically heterogeneous. Over the past decade mutations in genes encoding three ion channels, CACN1AS, SCN4A and KCNJ2, have been iden...
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This review of the primary familial periodic paralyses (PFPP) summarizes the pertinent clinical and laboratory findings of the three forms of this dis order. The review is intended to highlight diagnostic features of PFPP and to discuss current hypotheses regarding pathogenesis.
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ژورنال
عنوان ژورنال: Brain
سال: 2005
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awh639